新未名空间

我可买了不少

氨基葡萄糖会增加阿尔茨海默氏症的风险

Hyperglycosylation is a metabolic driver of Alzheimer’s diseaseTara R. Hawkinson, Zizhen Liu, …Ramon C. Sun Show authorsNature Metabolism (2026) Cite this article

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AbstractAlzheimer’s disease (AD) is a devastating neurodegenerative disorder marked by progressive cognitive decline. Metabolic disruptions are widely observed, yet their involvement in the molecular aetiology of AD remains underexplored. Here we identify hyperglycosylation as a driver of AD. Integrating spatial metabolomics, lipidomics and glycomics in transgenic AD mouse models and post-mortem human AD samples, along with advanced spatial isotopic tracing pulse-chase analysis of N-linked glycans, we demonstrate that the conserved phenotype of brain hyperglycosylation is driven by increased glycan biosynthesis. Genetic knockdown of glycan biosynthetic enzymes improves cognitive outcomes in AD mice whereas oral glucosamine supplementation impairs them. A retrospective analysis of electronic health records from patients with AD with varying disease severity shows that glucosamine supplementation is associated with accelerated AD progression and worsened survival. Overall, these results establish hyperglycosylation as a pathological driver of AD and highlight glycan metabolism as an actionable target in the fight against AD.

甚好

这个呢

https://www.costco.com/p/-/kirkland-sig ... s/11245398

这个呢 我平时当保健品吃

https://www.costco.com/p/-/kirkland-sig ... s/11245398

yanb 写了： 2026年 6月 16日 09:03

这个呢

https://www.costco.com/p/-/kirkland-sig ... s/11245398

完了 你已经老年痴呆了
Glucosamine 就在主帖里和你的链接里

完了完了

https://www.zaobao.com.sg/news/world/st ... 13-9199061

microfish 写了： 2026年 6月 16日 06:31

我可买了不少

氨基葡萄糖会增加阿尔茨海默氏症的风险

Hyperglycosylation is a metabolic driver of Alzheimer’s diseaseTara R. Hawkinson, Zizhen Liu, …Ramon C. Sun Show authorsNature Metabolism (2026) Cite this article

18k Accesses

1 Citations

763 Altmetric

Metricsdetails

AbstractAlzheimer’s disease (AD) is a devastating neurodegenerative disorder marked by progressive cognitive decline. Metabolic disruptions are widely observed, yet their involvement in the molecular aetiology of AD remains underexplored. Here we identify hyperglycosylation as a driver of AD. Integrating spatial metabolomics, lipidomics and glycomics in transgenic AD mouse models and post-mortem human AD samples, along with advanced spatial isotopic tracing pulse-chase analysis of N-linked glycans, we demonstrate that the conserved phenotype of brain hyperglycosylation is driven by increased glycan biosynthesis. Genetic knockdown of glycan biosynthetic enzymes improves cognitive outcomes in AD mice whereas oral glucosamine supplementation impairs them. A retrospective analysis of electronic health records from patients with AD with varying disease severity shows that glucosamine supplementation is associated with accelerated AD progression and worsened survival. Overall, these results establish hyperglycosylation as a pathological driver of AD and highlight glycan metabolism as an actionable target in the fight against AD.

microfish 写了： 2026年 6月 16日 09:08

完了 你已经老年痴呆了
Glucosamine 就在主帖里和你的链接里

那这些药还在生产？
我好像给爸妈带过一次glucosamine。movefree他们不要。还带过辅酶q10和善存片，善存片每次都带。这些里面有这个氨基葡萄糖吗？氨基葡萄糖有这个风险，那是不是应该变成柜台药，有医生的许可才能吃……

它不是虚假广告被告，都退钱了吗？

前些年class action赔的把purchase cost抵消了

wh 写了： 2026年 6月 27日 20:28

那这些药还在生产？
我好像给爸妈带过一次glucosamine。movefree他们不要。还带过辅酶q10和善存片，善存片每次都带。这些里面有这个氨基葡萄糖吗？氨基葡萄糖有这个风险，那是不是应该变成柜台药，有医生的许可才能吃……

这仅是一篇文章，没有定论。这种事情也很多就是

完了，叔天天吃

clock 写了： 2026年 6月 27日 20:31

完了，叔天天吃

patpat. movefree还是glucosamine？要不要停一停……

Xiaofish 写了： 2026年 6月 27日 20:30

它不是虚假广告被告，都退钱了吗？

虚假广告了啥？

https://topclassactions.com/lawsuit-set ... ettlement/

wh 写了： 2026年 6月 27日 20:35

虚假广告了啥？

clock 写了： 2026年 6月 27日 20:31

完了，叔天天吃

完了，迷途

这玩意前几年有个集体诉讼，说广告误导，还给买过的人退了些钱

microfish 写了： 2026年 6月 16日 06:31

我可买了不少

氨基葡萄糖会增加阿尔茨海默氏症的风险

Hyperglycosylation is a metabolic driver of Alzheimer’s diseaseTara R. Hawkinson, Zizhen Liu, …Ramon C. Sun Show authorsNature Metabolism (2026) Cite this article

18k Accesses

1 Citations

763 Altmetric

Metricsdetails

AbstractAlzheimer’s disease (AD) is a devastating neurodegenerative disorder marked by progressive cognitive decline. Metabolic disruptions are widely observed, yet their involvement in the molecular aetiology of AD remains underexplored. Here we identify hyperglycosylation as a driver of AD. Integrating spatial metabolomics, lipidomics and glycomics in transgenic AD mouse models and post-mortem human AD samples, along with advanced spatial isotopic tracing pulse-chase analysis of N-linked glycans, we demonstrate that the conserved phenotype of brain hyperglycosylation is driven by increased glycan biosynthesis. Genetic knockdown of glycan biosynthetic enzymes improves cognitive outcomes in AD mice whereas oral glucosamine supplementation impairs them. A retrospective analysis of electronic health records from patients with AD with varying disease severity shows that glucosamine supplementation is associated with accelerated AD progression and worsened survival. Overall, these results establish hyperglycosylation as a pathological driver of AD and highlight glycan metabolism as an actionable target in the fight against AD.

哎我本人不信这些东西从来不吃

家人信，每次问带啥只要这个. 现在纠结了

沒事兒，接著吃

明年research就說今年這個是胡扯啦！

wh 写了： 2026年 6月 27日 20:34

patpat. movefree还是glucosamine？要不要停一停……

clock 写了： 2026年 6月 27日 20:44

沒事兒，接著吃

明年research就說今年這個是胡扯啦！