Scientists express horror over the creation of a virus that could render the human immune system defenceless
https://www.independent.co.uk/news/scie ... 77088.html
独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
版主： Softfist
独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Exclusive: Controversial US scientist creates deadly new flu strain for pandemic research
Scientists express horror over the creation of a virus that could render the human immune system defenceless
https://www.independent.co.uk/news/scie ... 77088.html
Scientists express horror over the creation of a virus that could render the human immune system defenceless
https://www.independent.co.uk/news/scie ... 77088.html
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Exclusive: Controversial US scientist creates deadly new flu ..
https://timesofindia.indiatimes.com/hom ... 675076.cms
A controversial scientist who carried ou ..
Read more at:
http://timesofindia.indiatimes.com/arti ... aign=cppst
https://timesofindia.indiatimes.com/hom ... 675076.cms
A controversial scientist who carried ou ..
Read more at:
http://timesofindia.indiatimes.com/arti ... aign=cppst
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
EXCLUSIVE: Controversial experiments that could make bird flu more risky poised to resume
Two “gain of function” projects halted more than 4 years ago have passed new U.S. review process
https://www.science.org/content/article ... sed-resume
Two “gain of function” projects halted more than 4 years ago have passed new U.S. review process
https://www.science.org/content/article ... sed-resume
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Scientists condemn 'crazy, dangerous' creation of deadly airborne flu virus
https://www.theguardian.com/science/201 ... -flu-virus
https://www.theguardian.com/science/201 ... -flu-virus
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Scientists condemn 'crazy, dangerous' creation of deadly airborne flu virus
This article is more than 8 years old
Researchers say recreation of Spanish flu strain highlights risk of pandemic, but critics say work puts global population at risk
https://www.theguardian.com/science/201 ... -flu-virus
Scientists have created a life-threatening virus that closely resembles the 1918 Spanish flu strain that killed an estimated 50m people in an experiment labelled as "crazy" by opponents.
US researchers said the experiments were crucial for understanding the public health risk posed by viruses currently circulating in wild birds, but critics condemned the studies as dangerous and called on funders to stop the work.
Scientists at the University of Wisconsin-Madison used a technique called reverse genetics to build the virus from fragments of wild bird flu strains. They then mutated the virus to make it airborne to spread more easily from one animal to another.
"The work they are doing is absolutely crazy. The whole thing is exceedingly dangerous," said Lord May, the former president of the Royal Society and one time chief science adviser to the UK government. "Yes, there is a danger, but it's not arising form the viruses out there in the animals, it's arising from the labs of grossly ambitious people."
Influenza viruses circulate freely in wild bird populations. Most remain in chickens, ducks and other birds, but occasionally strains mutate into a form that can infect humans. The H5N1 bird flu strain has killed at least 386 people since 2003, according to WHO figures. The Spanish 1918 flu is thought to have come from birds too.
Writing in the journal Cell Host and Microbe Yoshihiro Kawaoka describes how his team analysed various bird flu viruses and found genes from several strains that were very similar to those that made up the 1918 human flu virus. They combined the bird flu genes into a single new virus, making a new pathogen that was only about 3% different from the 1918 human virus.
The freshly made virus – the first of several the team created – was more harmful to mice and ferrets than normal bird flu viruses, but not as dangerous as the 1918 strain. It did not spread between ferrets and none of the animals died. But the scientists went on to mutate the virus, to see what changes could make it spread. Seven mutations later, they had a more dangerous version that spread easily from animal to animal in tiny water droplets, the same way flu spreads in humans.
Kawaoka, who led the research in a high-security lab at the University of Wisconsin-Madison, said the work highlighted how flu viruses found in wild bird populations had the potential to adapt to humans and cause a pandemic.
Follow-up experiments showed that the 2009 swine flu vaccine and the anti-viral drug tamiflu should be effective against the virus. "This is important information for those making decisions about surveillance and pandemic preparedness," Kawaoka told the Guardian.
The work is the latest in a series of controversial studies that have split the scientific community. On the one side are researchers who create dangerous viruses in secure labs in the hope of learning how existing strains could mutate to make them a potential threat to humans. On the other are scientists who argue the work does little or nothing to help protect people, but instead puts the global population in more danger.
Marc Lipsitch, professor of epidemiology at Harvard School of Public Health, said: "I am worried that this signals a growing trend to make transmissible novel viruses willy-nilly, without strong public health rationale. This is a risky activity, even in the safest labs. Scientists should not take such risks without strong evidence that the work could save lives, which this paper does not provide," he added.
In an article published last month, Lipsitch argued that experiments like Kawaoka's could unleash a catastrophic pandemic if a virus escaped or was intentionally released from a high-security laboratory.
But Kawaoka defended the work, saying that critics failed to appreciate the impact of his and others' work on dangerous viruses. "There were discussions on the usefulness of stockpiling H5N1 [bird flu] vaccines until our H5N1 papers were published. Similarly, this paper strongly supports stockpiling anti-influenza drugs. If this is not a 'lifesaving benefit', what is?" he said.
Many of the groups that create dangerous viruses to understand their workings are funded by the US National Institutes of Health (NIH). Lord May said he suspected the NIH supported the work because officials there were "incompetent" and believed the justifications that scientists told them. "This is work that shouldn't be done. It's as simple as that," he said.
The experiments show that a 1918-like flu virus could emerge in the wild as bird viruses swap genes and mutate. "Influenza viruses readily swap genes to generate new viruses, so something like this could happen, especially since many of these viruses have circulated in recent years," Kawaoka said. The viruses "have the potential to become adapted to mammals and possibly cause a human pandemic," he added.
The study identifies particular mutations that made the virus spread so easily. But that is not much use for surveillance, said Lipsitch, because there are scores of other mutations that could have the same effect. "The chance that a virus very similar to the one they study will appear in nature is extremely remote," he said. Kawaoka argues that his team is fully aware of this, and that the underlying mechanisms that make the virus so dangerous are more important for preventing future pandemics.
Simon Wain-Hobson, a virologist at the Pasteur Institute in Paris, said he feared that governments and funding bodies would only take the risks seriously once an accident had happened. "It's madness, folly. It shows profound lack of respect for the collective decision-making process we've always shown in fighting infections. If society, the intelligent layperson, understood what was going on, they would say 'What the F are you doing?'"
Carole Heilman, director of microbiology and infectious diseases at the National Institute of Allergy and Infectious Diseases (Niaid) in the US, said: "This study was conducted as part of a research project on understanding the molecular mechanisms of virulence of the 1918 influenza virus. NIH peer review determined that the research was scientifically meritorious. It was also determined that the information gained had the potential to help public health agencies in their assessment of circulating and newly emerging strains. In addition, NIH determined that all the research was being done under appropriate biosafety conditions and with appropriate risk mitigation measures."
This article is more than 8 years old
Researchers say recreation of Spanish flu strain highlights risk of pandemic, but critics say work puts global population at risk
https://www.theguardian.com/science/201 ... -flu-virus
Scientists have created a life-threatening virus that closely resembles the 1918 Spanish flu strain that killed an estimated 50m people in an experiment labelled as "crazy" by opponents.
US researchers said the experiments were crucial for understanding the public health risk posed by viruses currently circulating in wild birds, but critics condemned the studies as dangerous and called on funders to stop the work.
Scientists at the University of Wisconsin-Madison used a technique called reverse genetics to build the virus from fragments of wild bird flu strains. They then mutated the virus to make it airborne to spread more easily from one animal to another.
"The work they are doing is absolutely crazy. The whole thing is exceedingly dangerous," said Lord May, the former president of the Royal Society and one time chief science adviser to the UK government. "Yes, there is a danger, but it's not arising form the viruses out there in the animals, it's arising from the labs of grossly ambitious people."
Influenza viruses circulate freely in wild bird populations. Most remain in chickens, ducks and other birds, but occasionally strains mutate into a form that can infect humans. The H5N1 bird flu strain has killed at least 386 people since 2003, according to WHO figures. The Spanish 1918 flu is thought to have come from birds too.
Writing in the journal Cell Host and Microbe Yoshihiro Kawaoka describes how his team analysed various bird flu viruses and found genes from several strains that were very similar to those that made up the 1918 human flu virus. They combined the bird flu genes into a single new virus, making a new pathogen that was only about 3% different from the 1918 human virus.
The freshly made virus – the first of several the team created – was more harmful to mice and ferrets than normal bird flu viruses, but not as dangerous as the 1918 strain. It did not spread between ferrets and none of the animals died. But the scientists went on to mutate the virus, to see what changes could make it spread. Seven mutations later, they had a more dangerous version that spread easily from animal to animal in tiny water droplets, the same way flu spreads in humans.
Kawaoka, who led the research in a high-security lab at the University of Wisconsin-Madison, said the work highlighted how flu viruses found in wild bird populations had the potential to adapt to humans and cause a pandemic.
Follow-up experiments showed that the 2009 swine flu vaccine and the anti-viral drug tamiflu should be effective against the virus. "This is important information for those making decisions about surveillance and pandemic preparedness," Kawaoka told the Guardian.
The work is the latest in a series of controversial studies that have split the scientific community. On the one side are researchers who create dangerous viruses in secure labs in the hope of learning how existing strains could mutate to make them a potential threat to humans. On the other are scientists who argue the work does little or nothing to help protect people, but instead puts the global population in more danger.
Marc Lipsitch, professor of epidemiology at Harvard School of Public Health, said: "I am worried that this signals a growing trend to make transmissible novel viruses willy-nilly, without strong public health rationale. This is a risky activity, even in the safest labs. Scientists should not take such risks without strong evidence that the work could save lives, which this paper does not provide," he added.
In an article published last month, Lipsitch argued that experiments like Kawaoka's could unleash a catastrophic pandemic if a virus escaped or was intentionally released from a high-security laboratory.
But Kawaoka defended the work, saying that critics failed to appreciate the impact of his and others' work on dangerous viruses. "There were discussions on the usefulness of stockpiling H5N1 [bird flu] vaccines until our H5N1 papers were published. Similarly, this paper strongly supports stockpiling anti-influenza drugs. If this is not a 'lifesaving benefit', what is?" he said.
Many of the groups that create dangerous viruses to understand their workings are funded by the US National Institutes of Health (NIH). Lord May said he suspected the NIH supported the work because officials there were "incompetent" and believed the justifications that scientists told them. "This is work that shouldn't be done. It's as simple as that," he said.
The experiments show that a 1918-like flu virus could emerge in the wild as bird viruses swap genes and mutate. "Influenza viruses readily swap genes to generate new viruses, so something like this could happen, especially since many of these viruses have circulated in recent years," Kawaoka said. The viruses "have the potential to become adapted to mammals and possibly cause a human pandemic," he added.
The study identifies particular mutations that made the virus spread so easily. But that is not much use for surveillance, said Lipsitch, because there are scores of other mutations that could have the same effect. "The chance that a virus very similar to the one they study will appear in nature is extremely remote," he said. Kawaoka argues that his team is fully aware of this, and that the underlying mechanisms that make the virus so dangerous are more important for preventing future pandemics.
Simon Wain-Hobson, a virologist at the Pasteur Institute in Paris, said he feared that governments and funding bodies would only take the risks seriously once an accident had happened. "It's madness, folly. It shows profound lack of respect for the collective decision-making process we've always shown in fighting infections. If society, the intelligent layperson, understood what was going on, they would say 'What the F are you doing?'"
Carole Heilman, director of microbiology and infectious diseases at the National Institute of Allergy and Infectious Diseases (Niaid) in the US, said: "This study was conducted as part of a research project on understanding the molecular mechanisms of virulence of the 1918 influenza virus. NIH peer review determined that the research was scientifically meritorious. It was also determined that the information gained had the potential to help public health agencies in their assessment of circulating and newly emerging strains. In addition, NIH determined that all the research was being done under appropriate biosafety conditions and with appropriate risk mitigation measures."
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
由于731用大量中国人活体试验，太君有深厚的功底制造病毒。太君投美后，美军方全面掌控太君技术
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Scientists Will Create A Deadly New Flu Strain, Just To Prove They Can
https://www.forbes.com/sites/stevensalz ... c18274391d
https://www.forbes.com/sites/stevensalz ... c18274391d
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Proposed Experiments on Deadly Flu Virus Stir Controversy
https://www.healthline.com/health-news/ ... rsy-080713
https://www.healthline.com/health-news/ ... rsy-080713
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Controversial US scientist creates deadly new flu strain for pandemic research
https://www.panorama.am/en/news/2014/07 ... rch/251435
https://www.panorama.am/en/news/2014/07 ... rch/251435
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Is this wise? Controversial scientist recreates pandemic flu virus that killed 500,000 people... except it's WORSE
https://www.dailymail.co.uk/news/articl ... ccine.html
https://www.dailymail.co.uk/news/articl ... ccine.html
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Epicenter: Kawaoka and his team have been experimenting with deadly flue viruses in his state-of-the-art lab at the University of Wisconsin's Institute for Influenza Virus Research
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Scientists Have Re-Created The Deadly 1918 Flu Virus. Why?
https://www.forbes.com/sites/stevensalz ... 147c963190
https://www.forbes.com/sites/stevensalz ... 147c963190
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
Researchers at UW lab create close copy of 'Spanish flu' pandemic virus
https://archive.jsonline.com/news/healt ... 4971.html/
https://archive.jsonline.com/news/healt ... 4971.html/
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
A New Lab-Made COVID-19 Virus Puts Gain-of-Function Research Under the Microscope
https://time.com/6225643/lab-made-covid ... ntroversy/
https://time.com/6225643/lab-made-covid ... ntroversy/
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
beijingren3 写了： 2022年 12月 17日 18:17 Exclusive: Controversial US scientist creates deadly new flu strain for pandemic research
Scientists express horror over the creation of a virus that could render the human immune system defenceless
https://www.independent.co.uk/news/scie ... 77088.html
稳了，
你们这些法轮功和民运都是低级黑高级红，为反而反，从来不知道实事求是。NMB不干正事，整天喊什么“中共邪教、天灭中共”这种智障傻逼话，只会让正常人更反感反共这群人，这就是为什么现在都把这群傻逼称为轮子和民逗，真是成事不足败事有余，我都怀疑是不是已经被共产党收买了故意这么搞的。还有民逗整天制造低水平智障谣言，企图用一个谎言去击败另一个谎言，但是当谎言被戳穿就再也没有人相信你了。前几年墙内大面积转向粉红的重要原因之一就是各种民逗和sb公知炮制的谎言被戳穿了。
Re: 独家：有争议的美国科学家为大流行研究创造了致命的新流感毒株, 科学家们对创造一种可能使人类免疫系统失去防御能力的病毒表示恐惧
HIGH CONTAINMENT
Lab That Created Risky Avian Flu Had “Unacceptable” Biosafety Protocols
https://theintercept.com/2022/11/01/bio ... avian-flu/
Lab That Created Risky Avian Flu Had “Unacceptable” Biosafety Protocols
https://theintercept.com/2022/11/01/bio ... avian-flu/