Trouble is likely because a direct in-place upgrade from Windows 10 Home to Windows 10 IoT Enterprise LTSC is not officially supported by Microsoft. You will most likely need to perform a clean installation, which means your files, applications, and settings will not be kept. While registry modifications can sometimes force an in-place upgrade, this method is unsupported, carries risks, and is not recommended for users.
Recommended Approach: Clean Installation
Back up your data: Before proceeding, back up all important files, photos, and documents to an external drive or cloud storage.
Obtain a valid LTSC license: Ensure you have a legitimate license key for Windows 10 IoT Enterprise LTSC 2021, as a Home license is not compatible.
Perform a clean installation: Boot your computer from the LTSC installation media (like a USB drive) and choose to perform a clean install. This will wipe the existing Windows installation and install LTSC fresh.
Reinstall applications and restore data: After the clean installation, you will need to reinstall your applications and restore your data from your backup.
Potential Issues with LTSC
Driver Issues: Some hardware, particularly Nvidia GPU drivers, can cause issues during the LTSC upgrade/installation process, sometimes requiring a clean driver removal using a tool like Display Driver Uninstaller (DDU).
Application Compatibility: LTSC is designed for embedded systems. While it runs most tasks, some apps or features may not work as expected, especially if they rely on components removed in LTSC, such as the Microsoft Store.